Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens

It is widely accepted that tissue dendritic cells (DC) function as immune sentinels by alerting T cells to foreign antigen after delivering and presenting it in the draining lymph nodes. Over the last two decades, studies in animal models, particularly rodents, have demonstrated that respiratory tra...

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Bibliographic Details
Published inImmunology and cell biology Vol. 85; no. 3; pp. 182 - 188
Main Authors Wikstrom, Matthew E, Stumbles, Philip A
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.04.2007
Blackwell Science Ltd
Subjects
airway
Animals
antigen
Antigens - immunology
dendritic cell
Dendritic Cells - cytology
Dendritic Cells - immunology
Humans
lung
Mice
mouse
Respiratory System - cytology
Respiratory System - immunology
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Summary:It is widely accepted that tissue dendritic cells (DC) function as immune sentinels by alerting T cells to foreign antigen after delivering and presenting it in the draining lymph nodes. Over the last two decades, studies in animal models, particularly rodents, have demonstrated that respiratory tract DC are crucial for the adaptive immune response to inhaled antigen. Indeed, the fate of inhaled antigen is inextricably linked to the function of respiratory tract DC. In this review, we will discuss the characteristics of respiratory tract DC from mice and recent data that may help to explain their role in the fate of inhaled antigen.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0818-9641
1440-1711
DOI:10.1038/sj.icb.7100039