A 10-item smell identification scale related to risk for Alzheimer's disease

• Published in: Annals of neurology Vol. 58; no. 1; pp. 155 - 160
• Main Authors: Tabert, Matthias H., Liu, Xinhua, Doty, Richard L., Serby, Michael, Zamora, Diana, Pelton, Gregory H., Marder, Karen, Albers, Mark W., Stern, Yaakov, Devanand, D. P.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2005; Willey-Liss
• Subjects: Aged; Alzheimer Disease - diagnosis; Biological and medical sciences; Cognition Disorders - diagnosis; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Risk Factors; Sensory Thresholds - physiology; Smell - physiology; Nervous system diseases; Degenerative disease; Alzheimer disease; Central nervous system disease; Risk factor; Cerebral disorder
• ISSN: 0364-5134; 1531-8249
• DOI: 10.1002/ana.20533

University of Pennsylvania Smell Identification Test data from control subjects (n = 63), patients with mild cognitive impairment (n = 147), and patients with Alzheimer's disease (n = 100) were analyzed to derive an optimal subset of items related to risk for Alzheimer's disease (ie, healthy through mild cognitive impairment to early and moderate disease stages). The derived 10‐item scale performed comparably with the University of Pennsylvania Smell Identification Test in classifying subjects, and it strongly predicted conversion to Alzheimer's disease on follow‐up evaluation in patients with mild cognitive impairment. Independent replication is needed to validate these findings. Ann Neurol 2005;58:155–160