Age‐specific birth rates in women with epilepsy: a population‐based study

• Published in: Brain and behavior Vol. 6; no. 8; pp. e00492 - n/a
• Main Authors: Farmen, Anette Huuse, Grundt, Jacob Holter, Tomson, Torbjörn, Nakken, Karl O., Nakling, Jakob, Mowinchel, Petter, Øie, Merete, Lossius, Morten I.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2016; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Age groups; Birth control; Birth Rate; birth rates; Contraception Behavior - statistics & numerical data; Contraceptives, Oral, Hormonal; Epilepsy; Epilepsy - epidemiology; Female; fertility in epilepsy; Humans; Medicin och hälsovetenskap; Middle Aged; Norway - epidemiology; Obstetrics; Original Research; Population; Population-based studies; Pregnancy; Pregnancy Complications - epidemiology; Registries - statistics & numerical data; Studies; Ultrasonic imaging; Womens health; Young Adult; Norway; fertility in epilepsy; birth rates; pregnancy
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.492

Objective The aim of this study was to investigate birth rates and use of hormonal contraception in different age groups among women with epilepsy (WWE) in comparison to women without epilepsy. Materials and Methods Demographic data and medical information on more than 25,000 pregnant women (40,000 births), representing 95% of all pregnancies in Oppland County, Norway, were registered in the Oppland Perinatal Database in the period 1989–2011. Data were analyzed with respect to epilepsy diagnoses, and 176 women with a validated epilepsy diagnosis (303 pregnancies) were identified. Age‐specific birth rates in these women were estimated and compared with age‐specific birth rates in women without epilepsy in the same county. Results In WWE over 25 years of age, birth rates were significantly lower than in those of the same age group without epilepsy. In women below 20 years of age, birth rates were similar in those with and without epilepsy. The use of hormonal contraceptives prior to pregnancy was lower among WWE under 25 years than in the corresponding age group without epilepsy. Conclusions Health professionals who counsel WWE who are of fertile age should be aware of the strongly reduced birth rates in WWE over 25 years of age, and the lower rates of use of contraceptives among young WWE. In the birth registry Oppland Perinatal Database, birth rates in women with epilepsy were equal to women without epilepsy before the age of 20, then decreased significantly. The use of hormonal contraception was significantly lower in the younger epilepsy group compared to women without epilepsy.