Variation in the deposition of the antibodies at different anatomical sites in linear IgA disease of adults and chronic bullous disease of childhood

The diagnosis of linear IgA disease of adults (LAD) and chronic bullous disease of childhood (CBDC) relies upon finding a linear band of IgA at the basement membrane zone on direct immunofluorescence. This study examines the regional variation in antigen expression in the skin of affected individual...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of dermatology (1951) Vol. 127; no. 5; p. 482
Main Authors Collier, P M, Wojnarowska, F, Millard, P R
Format Journal Article
LanguageEnglish
Published England 01.11.1992
Subjects
Adolescent
Aged
Autoantibodies - immunology
Autoimmune Diseases - immunology
Basement Membrane - immunology
Buttocks
Female
Forearm
Humans
Infant
Lip
Male
Middle Aged
Skin - immunology
Skin Diseases, Vesiculobullous - immunology
Thigh
Online AccessGet more information

Cover

More Information
Summary:The diagnosis of linear IgA disease of adults (LAD) and chronic bullous disease of childhood (CBDC) relies upon finding a linear band of IgA at the basement membrane zone on direct immunofluorescence. This study examines the regional variation in antigen expression in the skin of affected individuals. Direct immunofluorescence was performed on biopsies from four different sites in 17 patients with these diseases. In two patients a biopsy from the volar surface of the forearm was negative, but other sites were positive; in the remaining patients there was no variation in antibody expression with site. It is therefore recommended that, if a single diagnostic biopsy is to be taken, the volar surface of the forearm is avoided.
ISSN:0007-0963
DOI:10.1111/j.1365-2133.1992.tb14844.x