Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

Three in one: Verruculogen synthase FtmF is a key enzyme to diversify the fumitremorgin biosynthetic pathway in Aspergillus fumigatus: FtmF catalyzes not only endoperoxide bond formation of verruculogen but also the deprenylation and oxidation of fumitremorgin B to yield 12α,13α‐dihydroxyfumitremorg...

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Published inChembiochem : a European journal of chemical biology Vol. 12; no. 5; pp. 711 - 714
Main Authors Kato, Naoki, Suzuki , Hirokazu, Takagi, Hiroshi, Uramoto, Masakazu, Takahashi, Shunji, Osada, Hiroyuki
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 21.03.2011
WILEY‐VCH Verlag
Subjects
Aspergillus fumigatus
Aspergillus fumigatus - enzymology
Aspergillus fumigatus - genetics
biosynthesis
dioxygenase
Dioxygenases - genetics
Dioxygenases - metabolism
endoperoxide bond
Genes, Fungal
Indoles - metabolism
natural products
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Summary:Three in one: Verruculogen synthase FtmF is a key enzyme to diversify the fumitremorgin biosynthetic pathway in Aspergillus fumigatus: FtmF catalyzes not only endoperoxide bond formation of verruculogen but also the deprenylation and oxidation of fumitremorgin B to yield 12α,13α‐dihydroxyfumitremorgin C and 13‐oxoverruculogen, respectively.
Bibliography:RIKEN
ArticleID:CBIC201000562
Ministry of Education, Culture, Sports, Science, and Technology of Japan
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istex:6EA032C2DA7D38EC36C86EFF7C47A90929B62BE8
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201000562