Febrile seizures in the predisposed brain: A new model of temporal lobe epilepsy
The atypical febrile seizure has important clinical implications because of its association with the mesial temporal lobe epilepsy syndrome, which is the most common of the intractable epilepsies. However, whether a causal relation exists between these conditions is currently unknown. We have previo...
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Published in | Annals of neurology Vol. 58; no. 1; pp. 41 - 49 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.07.2005
Willey-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | The atypical febrile seizure has important clinical implications because of its association with the mesial temporal lobe epilepsy syndrome, which is the most common of the intractable epilepsies. However, whether a causal relation exists between these conditions is currently unknown. We have previously shown that a focal cortical lesion induced in the neonatal rat predisposes to the development of atypical hyperthermic seizures. We show here that 86% of the lesion plus hyperthermia group experience development of spontaneous recurrent seizures recorded from the amygdala ipsilateral to the lesion. Control rats did not have spontaneous recurrent behavioral or electrographic seizures. Lesioned rats with hyperthermic seizures also showed an impaired performance on the Morris water maze when compared with naive control rats, suggesting mild deficits in learning and memory. These findings support a link between the atypical febrile seizure and mesial temporal lobe epilepsy, and at the same time establish a new model for this condition through which new preventative and therapeutic strategies can be tested. Ann Neurol 2005 |
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Bibliography: | Canadian Institutes of Health Research in partnership with Epilepsy Canada ark:/67375/WNG-GZ1R3XQL-X ArticleID:ANA20512 The Hospital for Sick Children Foundation - No. XG03-068 Sainte-Justine Research Center - No. HSJ 02-001 istex:A218DFABFD9B7354194D8B72C7E03F407055140F ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0364-5134 1531-8249 |
DOI: | 10.1002/ana.20512 |