Cell Response to Carbon Nanotubes: Size-Dependent Intracellular Uptake Mechanism and Subcellular Fate

The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5–2 μm in length, 10–30 nm in diameter) are excluded from the interior of the cell; long single‐walled carbon nanotubes (L‐SWNTs) of...

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Bibliographic Details
Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 6; no. 21; pp. 2362 - 2366
Main Authors Kang, Bin, Chang, Shuquan, Dai, Yaodong, Yu, Decai, Chen, Da
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 05.11.2010
WILEY‐VCH Verlag
Subjects
Biological Transport
carbon nanotubes cellular uptake
cytotoxicity
Flow Cytometry
Hep G2 Cells
Humans
Microscopy, Confocal
Nanotubes, Carbon
size dependency
subcellular fate
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Summary:The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5–2 μm in length, 10–30 nm in diameter) are excluded from the interior of the cell; long single‐walled carbon nanotubes (L‐SWNTs) of length 100–200 nm (1–3 nm in diameter) are only internalized into cytoplasm, whereas short ones (S‐SWNTs) of length 50–100 nm partly reside in the cell nucleus.
Bibliography:istex:BAE6FF85E23FD240B8360E8EBFC1DCE5FF336CE4
ark:/67375/WNG-FJCQWVHD-B
ArticleID:SMLL201001260
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201001260