The Emerging Role of Visible Light in Melanocyte Biology and Skin Pigmentary Disorders: Friend or Foe?

Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at vary...

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Published inJournal of clinical medicine Vol. 12; no. 23; p. 7488
Main Authors He, Xuanxuan, Jin, Shanglin, Dai, Xiaoxi, Chen, Li, Xiang, Leihong, Zhang, Chengfeng
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2023
Subjects
Aging
Biology
Care and treatment
Chromophores
Circadian rhythm
Clinical medicine
Collagen
Development and progression
DNA damage
Electromagnetism
Fibroblasts
Health aspects
Kinases
laser
LEDs
Light
Melanocytes
melasma
Oxidative stress
Pathogenesis
Physiological aspects
pigmentary disorders
Pigmentation disorders
Radiation
Skin
visible light
vitiligo
China
IPL
laser
vitiligo
melasma
visible light
LEDs
pigmentary disorders
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Summary:Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at varying wavelengths on melanocyte biology and skin pigmentary disorders. Different VL wavelengths may impose positive or negative effects, depending on their interactions with specific chromophores, photoaging, ROS production, circadian rhythm and other photon-mediated reactions. Further in vivo and in vitro studies are required to establish the pathologic mechanisms and application principles of VL in pigmentary disorders, as well as optimal photoprotection with coverage against VL wavelengths.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12237488