Event-Related Potential, Time-frequency, and Functional Connectivity Facets of Local and Global Auditory Novelty Processing: An Intracranial Study in Humans

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 25; no. 11; pp. 4203 - 4212
• Main Authors: El Karoui, Imen, King, Jean-Remi, Sitt, Jacobo, Meyniel, Florent, Van Gaal, Simon, Hasboun, Dominique, Adam, Claude, Navarro, Vincent, Baulac, Michel, Dehaene, Stanislas, Cohen, Laurent, Naccache, Lionel
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press (OUP) 01.11.2015
• Subjects: Acoustic Stimulation; Adolescent; Adult; Auditory Perception - physiology; Bioengineering; Brain - physiopathology; Brain Mapping; Computer Science; Computer Vision and Pattern Recognition; Electroencephalography; Engineering Sciences; Epilepsy - pathology; Evoked Potentials - physiology; Face; Female; Humans; Image Processing; Imaging; Life Sciences; Male; Medical Imaging; Middle Aged; Neural Pathways - physiopathology; Neurobiology; Neurons and Cognition; Photic Stimulation; Signal and Image processing; Time Factors; Young Adult; mismatch negativity; time-frequency; connectivity; P300; intracranial recordings
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhu143

Auditory novelty detection has been associated with different cognitive processes. Bekinschtein et al. (2009) developed an experimental paradigm to dissociate these processes, using local and global novelty, which were associated, respectively, with automatic versus strategic perceptual processing. They have mostly been studied using event-related potentials (ERPs), but local spiking activity as indexed by gamma (60-120 Hz) power and interactions between brain regions as indexed by modulations in beta-band (13-25 Hz) power and functional connectivity have not been explored. We thus recorded 9 epileptic patients with intracranial electrodes to compare the precise dynamics of the responses to local and global novelty. Local novelty triggered an early response observed as an intracranial mismatch negativity (MMN) contemporary with a strong power increase in the gamma band and an increase in connectivity in the beta band. Importantly, all these responses were strictly confined to the temporal auditory cortex. In contrast, global novelty gave rise to a late ERP response distributed across brain areas, contemporary with a sustained power decrease in the beta band (13-25 Hz) and an increase in connectivity in the alpha band (8-13 Hz) within the frontal lobe. We discuss these multi-facet signatures in terms of conscious access to perceptual information.