Meiotic recombination intermediates and mismatch repair proteins

Mismatch repair proteins are a highly diverse group of proteins that interact with numerous DNA structures during DNA repair and replication. Here we review data for the role of Msh4, Msh5, Mlh1, Mlh3 and Exo1 in crossing over. Based on the paradigm of interactions developed from studies of mismatch...

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Bibliographic Details
Published inCytogenetic and genome research Vol. 107; no. 3-4; pp. 232 - 248
Main Authors Hoffmann, E.R., Borts, R.H.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2004
Subjects
Animals
Base Pair Mismatch - genetics
DNA Repair - genetics
DNA Repair - physiology
DNA Repair Enzymes
Exodeoxyribonucleases - metabolism
Humans
Meiosis - genetics
Meiosis - physiology
Proteins - metabolism
Recombination, Genetic - genetics
Recombination, Genetic - physiology
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Summary:Mismatch repair proteins are a highly diverse group of proteins that interact with numerous DNA structures during DNA repair and replication. Here we review data for the role of Msh4, Msh5, Mlh1, Mlh3 and Exo1 in crossing over. Based on the paradigm of interactions developed from studies of mismatch repair, we propose models for the mechanism of crossover implementation by Msh4/Msh5 and Mlh1/Mlh3.   
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ISBN:9783805578592
3805578598
ISSN:1424-8581
1424-859X
DOI:10.1159/000080601