In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism

• Published in: IEEE transactions on biomedical circuits and systems Vol. 10; no. 5; pp. 955 - 962
• Main Authors: Baj-Rossi, Camilla, Cavallini, Andrea, Kilinc, Enver G., Stradolini, Francesca, Jost, Tanja Rezzonico, Proietti, Michele, De Micheli, Giovanni, Grassi, Fabio, Dehollain, Catherine, Carrara, Sandro
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.10.2016; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Acetaminophen; Acetaminophen - blood; Animals; Biocompatibility; Biomembranes; Biosensing Techniques - instrumentation; Blood Chemical Analysis - instrumentation; Blood Glucose - analysis; Conductometry - instrumentation; Electrodes; Epoxy resin; Equipment Design; Equipment Failure Analysis; fully implantable biochip; Glucose; Implants; Leukocytes (neutrophilic); Male; Metabolism; Mice; Mice, Inbred C57BL; Miniaturization; Monitoring; Monitoring, Ambulatory - instrumentation; Packaging; Paracetamol; parylene C; polycarbo-nate membrane; Prostheses and Implants; Prototypes; Remote monitoring; Reproducibility of Results; Sensitivity and Specificity; Sensors; Wireless Technology - instrumentation
• ISSN: 1932-4545; 1940-9990
• DOI: 10.1109/TBCAS.2016.2584239

This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in mice for 30 days. ATP and neutrophil concentrations have been measured, at the implant site after the device was explanted, to assess the level of biocompatibility of the device. Finally, fully working prototypes of the device were implanted in mice and tested. The implanted devices were used to detect variations in the physiological concentrations of glucose and paracetamol. Data trends on these analytes have been successfully acquired and transmitted to the external base station. Glucose and paracetamol (also named acetaminophen) have been proposed in this research as model molecules for applications to personalized and translational medicine.