Cord-Blood Transplantation from an Unrelated Donor in an Adult with Chronic Myelogenous Leukemia

To circumvent the problems inherent in allogeneic bone marrow transplantation, allogeneic cord blood has been studied as an alternative source of hematopoietic stem cells. Preliminary results with cord blood from an HLA-matched sibling are encouraging, but the experience with this procedure is limit...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 335; no. 3; pp. 167 - 170
Main Authors Laporte, Jean-Philippe, Gorin, Norbert-Claude, Rubinstein, Pablo, Lesage, Sylvie, Portnoi, Marie-France, Barbu, Véronique, Lopez, Manuel, Douay, Luc, Najman, Albert
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 18.07.1996
Subjects
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood & organ donations
Bone marrow
Bone marrow, stem cells transplantation. Graft versus host reaction
Female
Fetal Blood - cytology
Fetal Blood - immunology
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Infant, Newborn
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
Male
Medical research
Medical sciences
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplants & implants
Human
Transfusion
Unrelated donor
Stem cell
Hematopoietic cell
Homograft
Malignant hemopathy
Case study
Myeloproliferative syndrome
Chronic
Treatment
Chronic myelocytic leukemia
Graft
Adult
Female
Umbilical cord
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Summary:To circumvent the problems inherent in allogeneic bone marrow transplantation, allogeneic cord blood has been studied as an alternative source of hematopoietic stem cells. Preliminary results with cord blood from an HLA-matched sibling are encouraging, but the experience with this procedure is limited. 1 – 5 Although some 200 transplantations of cord blood have been performed in children, 6 , 7 few have been performed in adults. We describe an adult with chronic myelogenous leukemia who underwent the transplantation of cord-blood stem cells successfully. Case Report A 26-year-old woman was found to have chronic myelogenous leukemia in July 1990. All the leukemic cells had . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199607183350304