Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans

• Published in: Biochemical and biophysical research communications Vol. 411; no. 2; pp. 416 - 420
• Main Authors: Xia, Yang, Irvine, Robin F., Giudici, Maria-Luisa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 29.07.2011; Academic Press
• Subjects: Alternative Splicing; Amino Acid Sequence; Animals; brain; Cercopithecus aethiops; COS Cells; exons; Humans; Isoenzymes - chemistry; Isoenzymes - genetics; Lipid kinase; Mice; Molecular Sequence Data; nucleotides; Phosphatidylinositol 4,5-bisphosphate; Phosphatidylinositol 4-phosphate 5-kinase; Phosphotransferases (Alcohol Group Acceptor) - chemistry; Phosphotransferases (Alcohol Group Acceptor) - genetics; PIP2; Rats; Splice variant; PIP5KI; Lipid kinase; Splice variant; Phosphatidylinositol 4-phosphate 5-kinase; Phosphatidylinositol 4,5-bisphosphate; PIP2

► In this study we investigate splice variation in the lipid kinase PI4P 5-kinase Iγ. ► We report a new splice variant in rodents. ► We show that this new variant has a wide tissue distribution. ► We show, by identifying a new human splice site, that humans also express this variant. ► Finally, we s...