Cutaneous squamous cell carcinoma in the organ transplant recipient

• Published in: Oral oncology Vol. 103; p. 104562
• Main Authors: Bibee, Kristin, Swartz, Andrew, Sridharan, Shaum, Kurten, Cornelius H.L., Wessel, Charles B., Skinner, Heath, Zandberg, Dan P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2020
• Subjects: Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - pathology; Cutaneous head and neck cancer; Humans; Immunosuppression; Immunotherapy; Organ Transplantation - adverse effects; Organ Transplantation - methods; Prognosis; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Squamous cell carcinoma; Transplant; Transplant Recipients - statistics & numerical data; Cutaneous head and neck cancer; Squamous cell carcinoma; Immunosuppression; Immunotherapy; Transplant
• ISSN: 1368-8375; 1879-0593
• DOI: 10.1016/j.oraloncology.2019.104562

•Cutaneous SCCs are more common and more aggressive in transplant recipients.•Primary and secondary prevention and patient education can decrease tumor burden.•Solid organ transplant patients often require multidisciplinary cancer care. One in twenty solid organ transplant recipients (SOTRs) will develop a highly morbid or fatal cutaneous carcinoma after transplantation. The majority of these cases develop on the head and neck and may require intervention on the part of dermatology, dermatologic surgery, otolaryngology, transplant medicine, radiation oncology, and medical oncology. In this review, we discuss the problem of cutaneous squamous cell carcinoma (cSCC) in SOTRs as well as the prognostic factors and management strategies to care for this population.