Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer developme...

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Published inBiology (Basel, Switzerland) Vol. 10; no. 2; p. 116
Main Authors Perez-Dominguez, Francisco, Carrillo-Beltrán, Diego, Blanco, Rancés, Muñoz, Juan P, León-Cruz, Grettell, Corvalan, Alejandro H, Urzúa, Ulises, Calaf, Gloria M, Aguayo, Francisco
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.02.2021
MDPI
Subjects
Adapter proteins
Antioxidants
Apoptosis
Binding sites
Carcinogenesis
Cell adhesion & migration
Cervical cancer
Chronic obstructive pulmonary disease
Human papillomavirus
Kinases
Lung cancer
Lymphocytes B
Lymphoma
NF-κB protein
Oxidative stress
Prokaryotes
Review
Transcription
Transcription factors
pirin
epithelial
cancer
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Summary:Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains a novel area of study. This review presents accumulating evidence on the contribution of Pirin in epithelial cancers, involved signaling pathways, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.
Bibliography:Equally contributed.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology10020116