Chemokine receptors and HIV-1: the fusion of two major research fields

• Published in: Immunology Today Vol. 20; no. 2; pp. 89 - 94
• Main Author: Horuk, Richard
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier B.V 01.02.1999
• Subjects: AIDS/HIV; Amino Acid Sequence; Amino Acid Substitution; Animals; CCR5; CD4 Antigens - genetics; CD4 Antigens - physiology; CD4-Positive T-Lymphocytes - virology; Chemokine receptor; Chemokines - physiology; CXCR4; Disease Progression; Gene Expression Regulation; HIV Envelope Protein gp120 - metabolism; HIV Infections - metabolism; HIV Infections - therapy; HIV Infections - virology; HIV-1 - classification; HIV-1 - physiology; HIV-1 co-receptors; human immunodeficiency virus 1; Macaca mulatta; Macromolecular Substances; Macrophages - virology; Molecular Sequence Data; Rabies virus; Receptors, CCR2; Receptors, CCR5 - chemistry; Receptors, CCR5 - genetics; Receptors, CCR5 - physiology; Receptors, Chemokine - chemistry; Receptors, Chemokine - genetics; Receptors, Chemokine - physiology; Receptors, CXCR4 - chemistry; Receptors, CXCR4 - genetics; Receptors, CXCR4 - physiology; Receptors, Cytokine - chemistry; Receptors, Cytokine - genetics; Receptors, Cytokine - physiology; Recombinant Fusion Proteins - metabolism; Seven-transmembrane domain; Structure-Activity Relationship; Vesicular stomatitis Indiana virus; Immunology; CXCR4; Pharmacology; HIV-1 co-receptors; Chemokine receptor; Seven-transmembrane domain; CCR5; Virology
• ISSN: 0167-5699
• DOI: 10.1016/S0167-5699(98)01396-6

Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that several of them are co-receptors for HIV-1. Here, Richard Horuk reviews the latest developments in chemokine receptor research with a particular focus on their role as HIV-1 co-receptors.