Association between serotonin transporter availability and hostility scores in healthy volunteers—A single photon emission computed tomography study with [ 123I] ADAM

• Published in: Psychiatry research Vol. 154; no. 3; pp. 281 - 284
• Main Authors: Yang, Yen Kuang, Yao, Wei Jen, Yeh, Tzung Lieh, Lee, I Hui, Chen, Kao Ching, Lu, Ru Band
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 15.04.2007; Elsevier
• Subjects: Adult; Biological and medical sciences; Brain - metabolism; Cinanserin - administration & dosage; Cinanserin - analogs & derivatives; Cinanserin - pharmacokinetics; Female; Hostility; Hostility scores; Humans; Injections, Intravenous; Iodine Radioisotopes - administration & dosage; Iodine Radioisotopes - pharmacokinetics; Male; Medical sciences; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiology; Serotonin Plasma Membrane Transport Proteins - metabolism; Serotonin transporter; SPECT; Tomography, Emission-Computed, Single-Photon; Hostility scores; SPECT; Serotonin transporter; Radionuclide study; Availability; Human; Healthy subject; Hostility; Single photon emission tomography; Photon
• ISSN: 0925-4927; 0165-1781; 1872-7506
• DOI: 10.1016/j.pscychresns.2006.11.010

The present study examined the relationship between serotonin transporter (SERT) availability and hostility scores in healthy volunteers. SERT availability was measured by using SPECT with [ 123I] ADAM in 10 healthy participants. Hostility was measured with the Cook–Medley Hostility Scale. Hostile attribution, but not the other subscales of hostility, was negatively correlated with SERT availability. Central serotoninergic activities may play a role in hostility.