Prediction of nephrotoxicity induced by cisplatin combination chemotherapy in gastric cancer patients

• Published in: World journal of gastroenterology : WJG Vol. 17; no. 30; pp. 3510 - 3517
• Main Authors: Moon, Hyung Hwan, Seo, Kyung Won, Yoon, Ki Young, Shin, Yeon Myung, Choi, Kyung Hyun, Lee, Sang Ho
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 14.08.2011
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - physiopathology; Aged; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Brief; Cisplatin - administration & dosage; Cisplatin - adverse effects; Cisplatin - pharmacology; Cisplatin - therapeutic use; Drug Therapy, Combination; Glomerular Filtration Rate - drug effects; Humans; Kidney - drug effects; Kidney - physiology; Middle Aged; Retrospective Studies; Stomach Neoplasms - drug therapy; 化疗; 急性肾功能衰竭; 患者; 肾毒性; 胃癌; 诱导; 顺铂; 预测; Nephrotoxicity; Acute renal failure; Cisplatin; Drug toxicities
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i30.3510

AIM： To evaluate the treatment options for nephrotoxicity due to cisplatin combination chemotherapy. METHODS： We retrospectively reviewed patients who had received cisplatin combination chemotherapy for gastric cancer between January 2002 and December 2008. We investigated patients who had shown acute renal failure （ARF）, and examined their clinical characteristics, laboratory data, use of preventive measures, treatment cycles, the amount of cisplatin administered, recovery period, subsequent treatments, and renal status between the recovered and unrecovered groups. RESULTS： Forty-one of the 552 patients had serum creatinine （SCR） levels greater than 1.5 mg/dL. We found that pre-ARF SCR, ARF SCR, and ARF glomerular filtration rates were significantly associated with renal status post- ARF between the two groups （P = 0.008, 0.026, 0.026, respectively）. On the receiver operating characteristic curve of these values, a 1.75 mg/dL ARF SCR value had 87.5% sensitivity and 84.8% specificity （P = 0.011）.CONCLUSION： Cessation or reduction of chemotherapy should be considered for patients who have an elevation of SCR levels during cisplatin combination chemotherapy.