Induction of apoptosis by grape seed extract (Vitis vinifera) in oral squamous cell carcinoma

• Published in: Biomolecules & biomedicine Vol. 13; no. 3; pp. 186 - 191
• Main Authors: Aghbali, Amirala, Hosseini, Sepideh Vosough, Delazar, Abbas, Gharavi, Nader Kalbasi, Shahneh, Fatemeh Zare, Orangi, Mona, Bandehagh, Ali, Baradaran, Behzad
• Format: Journal Article
• Language: English
• Published: Bosnia and Herzegovina Association of Basic Medical Sciences 01.08.2013; Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
• Subjects: Anticancer; Antineoplastic Agents - pharmacology; Apoptosis; Carcinoma, Squamous Cell - pathology; Care and treatment; Cell Line, Tumor; Cell Proliferation - drug effects; cytotoxicity; DNA Fragmentation; Drug Screening Assays, Antitumor; Grape seed extract; Grape Seed Extract - pharmacology; Health aspects; Human Umbilical Vein Endothelial Cells; Humans; Mouth cancer; Mouth Neoplasms - pathology; oral squamous cell carcinoma; Squamous cell carcinoma; Vitis - chemistry; Bosnia and Herzegovina

Development of novel therapeutic modalities is crucial for the treatment of oral squamous cell carcinoma (OSCC). Recent scientific studies have been focused on herbal medicines as potent anti-cancer drug candidates. This study is the first to investigate the cytotoxic effects and the mechanism of ce...