HFA-PEFF scores: prognostic value in heart failure with preserved left ventricular ejection fraction

• Published in: The Korean journal of internal medicine Vol. 37; no. 1; pp. 96 - 108
• Main Authors: Egashira, Koichi, Sueta, Daisuke, Komorita, Takashi, Yamamoto, Eiichiro, Usuku, Hiroki, Tokitsu, Takanori, Fujisue, Koichiro, Nishihara, Taiki, Oike, Fumi, Takae, Masafumi, Hanatani, Shinsuke, Takashio, Seiji, Ito, Miwa, Yamanaga, Kenshi, Araki, Satoshi, Soejima, Hirofumi, Kaikita, Koichi, Matsushita, Kenichi, Tsujita, Kenichi
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Association of Internal Medicine 01.01.2022; The Korean Association of Internal Medicine; 대한내과학회
• Subjects: follow-up studies; Heart; heart failure; Heart Failure - diagnosis; Humans; Original; Prognosis; Stroke Volume; Ventricular Function, Left; 내과학; Heart failure; Follow-up studies; Prognosis
• ISSN: 1226-3303; 2005-6648
• DOI: 10.3904/kjim.2021.272

The Heart Failure Association (HFA)-PEFF score is recognized as a simple method to diagnose heart failure (HF) with preserved ejection fraction (HFpEF). This study aimed to evaluate the relationship between HFA-PEFF scores and cardiovascular outcomes in HFpEF patients. A total of 502 consecutive HFpEF patients were prospectively observed for up to 1,500 days. Cardiovascular outcomes were compared between two groups of patients, defined by their HFA-PEFF scores: those who scored 2-4 (the intermediate-score group) and those who scored 5-6 group (the high-score group). Overall, 236 cardiovascular events were observed during the follow-up period (median, 1,159 days). Kaplan-Meier analysis showed that there were significant differences in composite cardiovascular events and HF-related events between the intermediate-score group and the high-score group (p = 0.003 and p < 0.001, respectively). Multivariate Cox proportional hazards analysis showed that the HFA-PEFF scores significantly predicted future HF-related events (hazard ratio, 1.66; 95% confidence interval [CI], 1.11 to 2.50; p = 0.014); receiver operating characteristic analysis confirmed this relationship (area under the curve, 0.633; 95% CI, 0.574 to 0.692; p < 0.001). The cutoff HFA-PEFF score for the identification of HF-related events was 4.5. Decision curve analysis revealed that combining the HFA-PEFF score with conventional prognostic factors improved the prediction of HF-related events. HFA-PEFF scores may be useful for predicting HF-related events in HFpEF patients.