Utility of Liver Biopsy in the Diagnosis and Management of Possible Drug-Induced Liver Injury in Patients Receiving Antituberculosis Therapy: A Retrospective Study

• Published in: Infectious disease reports Vol. 15; no. 6; pp. 735 - 746
• Main Authors: Gualano, Gina, Zace, Drieda, Mosti, Silvia, Mencarini, Paola, Musso, Maria, Libertone, Raffaella, Cerva, Carlotta, Goletti, Delia, Rianda, Alessia, Del Nonno, Franca, Falasca, Laura, Palmieri, Fabrizio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.11.2023
• Subjects: Anticoagulants; antitubercular drugs; Biopsy; Cholestasis; Diagnosis; DILI diagnosis; Drugs; Granulomatous hepatitis; Hepatitis; hepatotoxicity; histology; HIV; Human immunodeficiency virus; Injuries; Liver; liver biopsy; Liver diseases; liver injury; Patients; Phosphatase; Tuberculosis; Ultrasonic imaging; Working groups; DILI management; DILI diagnosis; liver injury; histology; liver biopsy; hepatotoxicity; antitubercular drugs
• ISSN: 2036-7430; 2036-7449; 2036-7449
• DOI: 10.3390/idr15060066

Drug-induced liver injury (DILI) secondary to ATT treatment (TB-DILI) is reported in 2-28% of patients. We present here a series of clinical cases of suspected DILI arising during antituberculosis treatment, studied with the aid of liver biopsy. this was a retrospective descriptive study including 10 tuberculosis patients who underwent liver biopsy for suspected TB-DILI at the "Lazzaro Spallanzani" Institute from 2017 to 2022. Ten patients who underwent LB were extracted from the database and included in the retrospective study cohort. According to the clinical classification, eight patients had hepatocellular liver injury, one patient had cholestatic injury, and another had mixed-type injury. Histopathological diagnosis revealed liver damage due to DILI in 5/10 (50%) cases. In one case, liver biopsy showed necrotizing granulomatous hepatitis. Severe and persistent elevation of hepatic transaminases, hepatic cholestasis despite discontinuation of therapy, and other suspected hepatic conditions are indications for liver biopsy, which remains a valuable tool in the evaluation of selected tuberculosis patients with suspected DILI for many reasons. However, the decision to perform a liver biopsy should be based on clinical judgment, considering the benefits and risks of the procedure.