Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective

Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in cancer cells, these mechanisms can be altered to promote tumour d...

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Published inCancers Vol. 12; no. 1; p. 238
Main Authors Ong, Mei Shan, Deng, Shuo, Halim, Clarissa Esmeralda, Cai, Wanpei, Tan, Tuan Zea, Huang, Ruby Yun-Ju, Sethi, Gautam, Hooi, Shing Chuan, Kumar, Alan Prem, Yap, Celestial T.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.01.2020
MDPI
Subjects
Actin
Apoptosis
Cancer
Cancer therapies
Cell adhesion & migration
Cell division
Cytokeratin
Cytoskeleton
Endoplasmic reticulum
Filaments
Intermediate filaments
Intracellular
Invasiveness
Kinases
Medical prognosis
Melanoma
Metastasis
Microtubules
Mitochondria
Morphology
Motility
Mutation
Oxidative stress
Prostate
Proteins
Review
Tumorigenesis
Tumors
therapeutics
cancer
mitochondrial stress
cytoskeletal molecules
endoplasmic reticulum stress
oxidative stress
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Summary:Cytoskeletal proteins, which consist of different sub-families of proteins including microtubules, actin and intermediate filaments, are essential for survival and cellular processes in both normal as well as cancer cells. However, in cancer cells, these mechanisms can be altered to promote tumour development and progression, whereby the functions of cytoskeletal proteins are co-opted to facilitate increased migrative and invasive capabilities, proliferation, as well as resistance to cellular and environmental stresses. Herein, we discuss the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), and delineate the consequences of these responses, including effects on oncogenic signalling. In addition, we elaborate how the cytoskeleton and its associated molecules present themselves as therapeutic targets. The potential and limitations of targeting new classes of cytoskeletal proteins are also explored, in the context of developing novel strategies that impact cancer progression.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12010238