Surgical complications and graft function following live-donor extraperitoneal renal transplantation in children 20 kg or less

• Published in: Journal of pediatric urology Vol. 10; no. 4; pp. 737 - 743
• Main Authors: ElSheemy, Mohammed S, Shouman, Ahmed M, Shoukry, Ahmed I, Soaida, Sherif, Salah, Doaa M, Yousef, Ali M, Morsi, Hany A, Fadel, Fatina I, Sadek, Sameh Z
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2014
• Subjects: Adult; Body Weight; Child; Child, Preschool; Cohort Studies; Extraperitoneal approach; Female; Graft Rejection - epidemiology; Graft Survival; Humans; Immunosuppression; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - surgery; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Kidney Transplantation - mortality; Live donor; Living Donors; Low body weight children; Male; Middle Aged; Pediatric; Pediatrics; Renal transplantation; Survival Rate; Treatment Outcome; Urology; Low body weight children; Renal transplantation; Extraperitoneal approach; Live donor; Pediatric
• ISSN: 1477-5131; 1873-4898
• DOI: 10.1016/j.jpurol.2013.12.013

Abstract Objectives To evaluate the effect of patient, surgical, and medical factors on surgical complications and graft function following renal transplantation (Tx) in children weighing ≤20 kg, because the number of this challenging group of children is increasing. Patients and methods Between June 2009 and October 2013, 26 patients received living donor renal allotransplant using the extraperitoneal approach (EPA). The immunosuppression regimen was composed of prednisolone, mycophenolate mofetil, and ciclosporin or tacrolimus. Results The mean weight was 16.46 ± 2.61 kg. Mean cold ischemia time was 53.85 ± 12.35 min. The graft survival rate (GSR) and patient survival rate (PSR) were 96% at 3 years. Acute rejection episodes (AREs) occurred in eight patients (30%). Postoperative surgical complications were ureteral leakage (3), vesicoureteric reflux (2), and renal vein thrombosis (2) (with one graft nephrectomy). Mean follow-up was 37.5 ± 7.4 months. Conclusion Excellent PSR and GSR can be achieved in low weight (<20 kg) recipients. Even in very low weight patients, the EPA was used. No cases were reported with primary graft non-function due to use of living donors, increasing pre-Tx body weight to at least 10 kg and maintaining adequate filling pressure before graft reperfusion. The presence of related donors and use of induction therapy and tacrolimus decreased the rate of ARE while the presence of pre-Tx lower urinary tract surgical interventions increased the rate of ureteric complications, but this was statistically insignificant.