Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice

The mechanism of the analgesic effect of nitrous oxide (N 2 O) has not been completely clarified. Although we have reported that the analgesic effect of N 2 O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on...

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Bibliographic Details
Published inJournal of anesthesia Vol. 23; no. 2; pp. 301 - 303
Main Authors Koyama, Tomohiro, Fukuda, Kazuhiko
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 2009
Subjects
Acetic Acid
Aminoquinolines - pharmacology
Anesthesiology
Anesthetics, Inhalation - antagonists & inhibitors
Anesthetics, Inhalation - pharmacology
Animals
Benzamides - pharmacology
Critical Care Medicine
Emergency Medicine
Intensive
Male
Medicine
Medicine & Public Health
Mice
Narcotic Antagonists
Nitrous Oxide - antagonists & inhibitors
Nitrous Oxide - pharmacology
Pain Measurement - drug effects
Pain Medicine
Receptors, Opioid
Short Communication
Nociceptin
Analgesia
Nitrous oxide
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Summary:The mechanism of the analgesic effect of nitrous oxide (N 2 O) has not been completely clarified. Although we have reported that the analgesic effect of N 2 O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N 2 O-induced analgesia has not been reported. In this investigation, we examined the effect of the NOP antagonist JTC-801 on N 2 O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N 2 O was suppressed by the intraperitoneal administration of JTC-801.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-009-0739-2