Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice

The mechanism of the analgesic effect of nitrous oxide (N 2 O) has not been completely clarified. Although we have reported that the analgesic effect of N 2 O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on...

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Bibliographic Details
Published inJournal of anesthesia Vol. 23; no. 2; pp. 301 - 303
Main Authors Koyama, Tomohiro, Fukuda, Kazuhiko
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 2009
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Summary:The mechanism of the analgesic effect of nitrous oxide (N 2 O) has not been completely clarified. Although we have reported that the analgesic effect of N 2 O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N 2 O-induced analgesia has not been reported. In this investigation, we examined the effect of the NOP antagonist JTC-801 on N 2 O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N 2 O was suppressed by the intraperitoneal administration of JTC-801.
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content type line 23
ISSN:0913-8668
1438-8359
DOI:10.1007/s00540-009-0739-2