Role of regional neurotransmitter receptors in corticotropin-releasing factor (CRF)-mediated modulation of fear conditioning

• Published in: Neuropharmacology Vol. 39; no. 4; pp. 707 - 710
• Main Authors: Radulovic, Jelena, Fischer, Andre, Katerkamp, Ulrike, Spiess, Joachim
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.03.2000; Elsevier
• Subjects: Animals; Behavioral psychophysiology; Benzazepines - pharmacology; Biological and medical sciences; Conditioning (Psychology) - physiology; Corticotropin-Releasing Hormone - pharmacology; Corticotropin-Releasing Hormone - physiology; CRF; Dopamine Antagonists - pharmacology; Dopamine receptors; Excitatory Amino Acid Antagonists - pharmacology; Fear - physiology; Fundamental and applied biological sciences. Psychology; Hippocampus; Humans; Injections; Lateral septum; Learning; Male; Mice; Mice, Inbred BALB C; Muscarinic Antagonists - pharmacology; Muscarinic receptors; Neurotransmission and behavior; Pipecolic Acids - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Receptors, Dopamine D1 - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, Neurotransmitter - physiology; Scopolamine - pharmacology; Septum Pellucidum; Learning; Muscarinic receptors; CRF; Hippocampus; Lateral septum; Dopamine receptors; Dopamine receptor; Memory; Electrical stimulus; Rodentia; Corticotropin releasing factor; Central nervous system; Septum; Instrumental conditioning; Cognition; Strain specificity; Fear; Vertebrata; Mammalia; Mouse; Animal; Intracerebral administration; Muscarinic receptor; Antagonist; NMDA receptor; Brain (vertebrata); Biological receptor
• ISSN: 0028-3908; 1873-7064
• DOI: 10.1016/S0028-3908(99)00185-9

We have demonstrated previously that stimulation of hippocampal corticotropin-releasing factor (CRF) receptors enhances, whereas stimulation of CRF receptors in the lateral intermediate septum impairs learning, as indicated by fear conditioning. Here, we report that the action of CRF within the hippocampus and lateral septum require muscarinic and D2 receptors, respectively.