Pyrrolactams from Marine Sponge Stylissa massa Collected from Myanmar and Their Anti-Vpr Activities

• Published in: Chemical & pharmaceutical bulletin Vol. 69; no. 7; pp. 702 - 705
• Main Authors: Win, Nwet Nwet, Kodama, Takeshi, Aye, Aung Aung, Lae, Khine Zar Wynn, Ngwe, Hla, Han, Nang Mya, Abe, Ikuro, Morita, Hiroyuki
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.07.2021; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Absolute configuration; Antiviral agents; Bromination; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Circular dichroism; Dichroism; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Physical Sciences; pyrrolactam; Science & Technology; Stylissa; Stylissa massa; stylissaol A; TREx-HeLa-Viral protein R (Vpr); Vpr protein; Myanmar (Burma); pyrrolactam; BROMOPYRROLE ALKALOIDS; NATURAL-PRODUCTS; stylissaol A; Stylissa massa; TREx-HeLa-Viral protein R (Vpr); PROTEIN R INHIBITORS
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.c21-00227

A new brominated pyrrolactam stylissaol A (1) together with four known analogues, 2-bromoaldisine, aldisine, spongiacidin D, and Z-hymenialdisine, were isolated from the EtOAc extract of marine sponge Stylissa massa collected in Myanmar. The absolute configuration at C-10 of 1 was determined as R by the electronic circular dichroism (ECD) data. Among the isolated compounds, 2-bromoaldisine showed anti-Viral Protein R (Vpr) activity against TREx-HeLa-Vpr cells with an effective dose of 10 µM and its potency was comparable to that of positive control damnacanthal.