The Costs of Complications and Unplanned Readmissions after Pancreatoduodenectomy for Pancreatic and Periampullary Tumors: Results from a Single Academic Center

• Published in: Cancers Vol. 13; no. 24; p. 6271
• Main Authors: Linnemann, Ralph J A, Kooijman, Bob J L, van der Hilst, Christian S, Sprakel, Joost, Buis, Carlijn I, Kruijff, Schelto, Klaase, Joost M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.12.2021; MDPI
• Subjects: complication; costs; Ethics; Fistula; Health care; Hospital costs; Outpatient care facilities; pancreas; Pancreatic cancer; Pancreaticoduodenectomy; Patients; PPPD; readmission; Tumors; Whipple; United States > US; PPPD; costs; complication; Whipple; readmission; pancreas
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers13246271

Complications after pancreatoduodenectomy (PD) lead to unplanned readmissions (UR), with a two- to threefold increase in admission costs. In this study, we aimed to create an understanding of the costs of complications and UR in this patient group. Furthermore, we aimed to generate a detailed cost overview that can be used to build a theoretical model to calculate the cost efficacy for prehabilitation. A retrospective cohort analysis was performed using the Dutch Pancreatic Cancer Audit (DPCA) database of patients who underwent a PD at our institute between 2013 and 2017. The total costs of the index hospital admission and UR related to the PD were collected. Of the 160 patients; 35 patients (22%) had an uncomplicated course; 87 patients (54%) had minor complications, and 38 patients (24%) had severe complications. Median costs for an uncomplicated course were EUR 25.682, and for a complicated course, EUR 32.958 ( = 0.001). The median costs for minor complications were EUR 30.316, and for major complications, EUR 42.664 ( = 0.001). Costs were related to the Comprehensive Complication Index (CCI). The median costs of patients with one or more UR were EUR 41.199. Complications after PD led to a EUR 4.634-EUR 16.982 (18-66%) increase in hospital costs. A UR led to a cost increase of EUR 12.567 (44%). Since hospital costs are directly related to the CCI, reduction in complications will lead to cost-effectiveness.