Immunological Agnosis: A State That Derives from T Suppressor Cell Inhibition of Antigen-Presenting Cells

The biologically active mediators of antigen-specific T suppressor cells can combine with antigen on cells that are specialized to present antigen (APC) and render these APC incapable of presenting not only the specific antigen that the product of the T suppressor cell sees but also any other antige...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 79; no. 8; pp. 2645 - 2648
Main Authors Ptak, Wlodzimierz, Gershon, Richard K.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.04.1982
National Acad Sciences
Subjects
Animals
Antigen presenting cells
Antigens
Antigens, Surface - immunology
B lymphocytes
Haptens
Immunization
Immunology
Langerhans cells
Lymph Nodes - immunology
Macrophages
Mice
Mice, Inbred CBA
Spleen - immunology
Swelling
T lymphocytes
T-Lymphocytes, Regulatory - immunology
Thymus Gland - immunology
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Summary:The biologically active mediators of antigen-specific T suppressor cells can combine with antigen on cells that are specialized to present antigen (APC) and render these APC incapable of presenting not only the specific antigen that the product of the T suppressor cell sees but also any other antigen in or on the APC. Thus, antigen-bearing suppressed APC fail to activate either the helper or suppressor systems involved in the regulation of contact sensitivity responses. These results demonstrate that APC are targets of T suppressor cells. They also imply that a metabolic event is required for functional antigen presentation and that T suppressor cells can block that metabolic pathway.
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ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.79.8.2645