Genetic polymorphisms of CYP2D610 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia

• Published in: Journal of Zhejiang University. B. Science Vol. 16; no. 3; pp. 191 - 197
• Main Authors: Tang, Kai-fa, Zhao, Yi-li, Ding, Shang-shu, Wu, Qi-fei, Wang, Xing-yang, Shi, Jia-qi, Sun, Fa, Xing, Jun-ping
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.03.2015; Springer Nature B.V
• Subjects: Adult; Amino Acid Substitution; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Drug Therapy, Combination; Female; Follicle Stimulating Hormone - blood; Gene Frequency; Humans; Luteinizing Hormone - blood; Male; Oligospermia - drug therapy; Oligospermia - enzymology; Oligospermia - genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Pregnancy; Sperm Count; Sperm Motility - drug effects; Tamoxifen - administration & dosage; Testosterone - administration & dosage; Testosterone - analogs & derivatives; Testosterone - blood; Treatment Outcome; Young Adult; Testosterone; 性激素; Oligozoospermia; 细胞色素P450; Infertility; Cytochrome P450; R698.2; Tamoxifen; 他莫昔芬; 男性不育症; 少精子症
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.B1400282

Tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization (WHO), and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate and testosterone undecanoate in infertile men with idiopathic oligozoospermia, and whether the results would be affected by polymerphisms of CYP2D6*10 . A total of 230 infertile men and 147 controls were included in the study. Patients were treated with tamoxifen citrate and testosterone undecanoate. Sex hormone, sperm parameters, and incidence of spontaneous pregnancy were detected. There were no significant differences between the control and patient groups with respect to CYP2D6*10 genotype frequencies ( P >0.05). The follicle-stimulation hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were raised, and sperm concentration and motility were increased at 3 months and became significant at 6 months, and they were higher in the wild-type allele (C/C) than in the heterozygous variant allele (C/T) or homozygous variant allele (T/T) subgroups ( P <0.05). In addition, the percentage of normal morphology was raised at 6 months, and represented the highest percentage in the C/C subgroup ( P <0.05). The incidence of spontaneous pregnancy in the C/C subgroup was higher than that in the C/T or T/T subgroups ( P <0.01). This study showed that the CYP2D6*10 variant genotype demonstrated worse clinical effects in infertile men with idiopathic oligozoospermia.