The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass

• Published in: International journal of immunopharmacology Vol. 21; no. 8; pp. 531 - 540
• Main Authors: Hamano, Kimikazu, Gohra, Hidenori, Katoh, Tomoe, Fujimura, Yoshihiko, Zempo, Nobuya, Esato, Kensuke
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Science 01.08.1999
• Subjects: Adjuvants, Immunologic - administration & dosage; Aged; AIDS/HIV; Biological and medical sciences; Cardiac surgery; Cardiopulmonary bypass; Cardiopulmonary Bypass - adverse effects; CD4-CD8 Ratio - drug effects; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cytotoxicity, Immunologic - drug effects; Drug Administration Schedule; Female; Humans; Immunity; Immunomodulators; Injections, Intravenous; Killer Cells, Natural - drug effects; Killer Cells, Natural - immunology; Lentinan - administration & dosage; Leukocyte Count - drug effects; Lymphocyte Count - drug effects; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Premedication; Cardiopulmonary bypass; Immunity; Cardiac surgery; Heart; Human; Immune response; Intravenous administration; Basidiomycetes; Biological activity; Neoadjuvant treatment; Lentinus edodes; Fungi; Natural killer cell; Glucan; Immunostimulant agent; Surgery; T-Lymphocyte; Circulatory system; Preoperative; Thallophyta
• ISSN: 0192-0561; 1879-3495
• DOI: 10.1016/S0192-0561(99)00033-8

The aim of this study was to determine whether the preoperative administration of lentinan, which is used clinically to activate T cell function in cancer patients, prevents the impairment of lymphocyte function after cardiopulmonary bypass (CPB). A total of 25 adults undergoing coronary artery bypass grafting were enrolled in this study. Lentinan (2 mg) was given to 10 randomly selected patients 7 d before surgery, while the other 15 patients were considered as a control. The white blood cell count, percentage of lymphocytes, subsets of lymphocytes, and natural killer cell activity were measured preoperatively, immediately after CPB and 1, 3, and 6 d after surgery. The white blood cell counts and the percentage of lymphocytes were not significantly different between the two groups; however, the percentage of CD4-positive cells in the lentinan group recovered to normal more rapidly than in the control group. Although natural killer cell activity was impaired in the control group after CPB, it maintained a nearly normal level in the lentinan group. The preoperative administration of lentinan for patients undergoing CPB ameliorated the impairment of natural killer activity and promoted the rapid recovery of CD4-positive cells.