Strategies and Applications of in vitro Mutagenesis

The many mutagenesis strategies made possible by the availability of cloned genes have been outlined in the context of how each strategy lends itself to the answering of different kinds of biological questions.

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 229; no. 4719; pp. 1193 - 1201
Main Authors Botstein, David, Shortle, David
Format Journal Article
LanguageEnglish
Published Washington, DC The American Association for the Advancement of Science 20.09.1985
American Association for the Advancement of Science
Subjects
Alleles
Animals
Base Sequence
Biological and medical sciences
Biotechnology
Cloning, Molecular - methods
DNA
DNA Transposable Elements
DNA, Bacterial
DNA, Recombinant
Drosophila melanogaster - genetics
Escherichia coli - genetics
Fundamental and applied biological sciences. Psychology
Genes
Genetic mutation
Genetic technics
In Vitro Techniques
Methods. Procedures. Technologies
Molecular and cellular biology
Molecular biology
Molecular genetics
Molecules
Mutagenesis
Mutagenesis. Repair
Mutagenicity Tests - methods
Mutant screening
Mutation
Nucleotides
Oligonucleotides
Phenotype
Phenotypes
Plasmids
In vivo
Gene
Mutagenesis
Transposon
Site directed mutagenesis
Oligonucleotide
Review
Method
Molecular cloning
Application
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More Information
Summary:The many mutagenesis strategies made possible by the availability of cloned genes have been outlined in the context of how each strategy lends itself to the answering of different kinds of biological questions.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2994214