Metallomics approach to changes in element concentration during differentiation from fibroblasts into adipocytes by element array analysis

We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L...

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Bibliographic Details
Published inJournal of toxicological sciences Vol. 41; no. 2; pp. 241 - 244
Main Authors Ogra, Yasumitsu, Nagasaki, Shu, Yawata, Ayako, Anan, Yasumi, Hamada, Koichi, Mizutani, Akihiro
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Toxicology 01.04.2016
Japan Science and Technology Agency
Subjects
3T3-L1
3T3-L1 Cells
Adipocyte
Adipocytes - cytology
Adipocytes - metabolism
Animals
Cell Differentiation
Differentiation
Elements
Fibroblast
Fibroblasts - cytology
Fibroblasts - metabolism
Finite Element Analysis
Metabolomics - methods
Metallomics
Metals - metabolism
Mice
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Summary:We aimed to establish an element array analysis that involves the simultaneous detection of all elements in cells and the display of changes in element concentration before and after a cellular event. In this study, we demonstrated changes in element concentration during the differentiation of 3T3-L1 mouse fibroblasts into adipocytes. This metallomics approach yielded unique information of cellular response to physiological and toxicological events.
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ISSN:0388-1350
1880-3989
DOI:10.2131/jts.41.241