Opportunities and challenges in liquid cell electron microscopy

Transmission electron microscopy offers structural and compositional information with atomic resolution, but its use is restricted to thin, solid samples. Liquid samples, particularly those involving water, have been challenging because of the need to form a thin liquid layer that is stable within t...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 350; no. 6267; p. 1490
Main Author Ross, Frances M.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 18.12.2015
The American Association for the Advancement of Science
Subjects
Biology
Cellular biology
Chemistry
Crystals
Electron microscopy
Laboratory Equipment
Liquids
Microscopes
Physics
REVIEW SUMMARY
Stimuli
Thin films
Transmission electron microscopy
Water
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Summary:Transmission electron microscopy offers structural and compositional information with atomic resolution, but its use is restricted to thin, solid samples. Liquid samples, particularly those involving water, have been challenging because of the need to form a thin liquid layer that is stable within the microscope vacuum. Liquid cell electron microscopy is a developing technique that allows us to apply the powerful capabilities of the electron microscope to imaging and analysis of liquid specimens. We describe its impact in materials science and biology. We discuss how its applications have expanded via improvements in equipment and experimental techniques, enabling new capabilities and stimuli for samples in liquids, and offering the potential to solve grand challenge problems.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.aaa9886