Acquired Immunodeficiency Syndrome in a Colony of Macaque Monkeys

A naturally occurring immunodeficiency syndrome has been seen in a captive colony of macaque monkeys. This syndrome is seen primarily in the species Macaca cyclopis. Affected animals died with lymphomas (a rare disease in macaques) or such opportunistic infections as Pneumocystis carinii and noma (n...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 80; no. 9; pp. 2718 - 2722
Main Authors Letvin, Norman L., Eaton, Kathryn A., Aldrich, Wayne R., Sehgal, Prabhat K., Blake, Beverly J., Schlossman, Stuart F., King, Norval W., Hunt, Ronald D.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.05.1983
National Acad Sciences
Subjects
Acquired Immunodeficiency Syndrome - physiopathology
AIDS
AIDS/HIV
Animals
Autopsies
Disease Models, Animal
Diseases
Epidemiology
Female
Fluorescent Antibody Technique
Humans
Immune Tolerance
Leukocyte Count
Lymphocytes
Macaca
Male
Monocytes
Pneumocystis carinii
Primates
Species Specificity
T-Lymphocytes - immunology
T-Lymphocytes, Helper-Inducer - analysis
T-Lymphocytes, Regulatory - analysis
Tumors
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Summary:A naturally occurring immunodeficiency syndrome has been seen in a captive colony of macaque monkeys. This syndrome is seen primarily in the species Macaca cyclopis. Affected animals died with lymphomas (a rare disease in macaques) or such opportunistic infections as Pneumocystis carinii and noma (necrotizing gingivitis). These M. cyclopis exhibited anemia, neutropenia, and a circulating bizarre immature monocyte. In addition, liver function tests suggested hepatitis. Pokeweed mitogen-, concanavalin A-, and xenogeneic cell-stimulated proliferative responses by lymphocytes of animals with the syndrome were dramatically diminished. The T4 (helper, inducer)/T8 (suppressor, cytotoxic) ratio in the peripheral blood mononuclear T-cell populations of M. cyclopis in this colony are decreased when compared with those from either Macaca mulatta in the same colony or normal humans. Epidemiologic evidence implicates a common source agent in this syndrome. The similarity of this syndrome in macaques to human acquired immunodeficiency syndrome suggests that it may provide an important model for studying the human syndrome.
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ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.80.9.2718