Word retrieval difficulty in adult females with the FMR1 premutation: Changes over time and across contexts
•We examined word retrieval difficulty in female premutation carriers over eight years.•As women aged, they produced fewer words, fewer different words, and had more errors.•Word retrieval difficulty occurred much earlier than can be expected in healthy aging.•Subtle cognitive decline may be a facto...
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Published in | Brain and cognition Vol. 148; p. 105694 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.03.2021
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | •We examined word retrieval difficulty in female premutation carriers over eight years.•As women aged, they produced fewer words, fewer different words, and had more errors.•Word retrieval difficulty occurred much earlier than can be expected in healthy aging.•Subtle cognitive decline may be a factor of premutation carrier status for women.
Individuals with a premutation of the fragile X mental retardation (FMR1) gene are at risk for a variety of psychological, physical, and cognitive issues, including difficulty with word retrieval. The present study examined three indicators of word retrieval difficulty; reduced productivity, reduced lexical diversity, and increased errors in word retrieval in a group of 38 female premutation carriers during standard-length speech samples collected over a period of eight years. Our results revealed that as women aged, they produced fewer words, produced fewer different words, and had greater word retrieval errors. In addition, the rate of word retrieval errors was highly correlated between two speaking contexts, indicating that this difficulty was pervasive and not solely the result of speaking in monologue. Our results suggest that subtle areas of cognitive decline emerge at a much earlier age among female premutation carriers than would be expected during healthy aging. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 CRediT authorship contribution statement Shelley L. Bredin-Oja: Conceptualization, Methodology, Investigation, Writing – original draft, Writing – review & editing, Project administration. Steven F. Warren: Conceptualization, Writing – review & editing, Supervision, Funding acquisition. Rebecca Swinburne Romine: Methodology, Writing – original draft, Writing – review & editing, Visualization, Formal analysis. Kandace K. Fleming: Methodology, Writing – review & editing, Visualization, Formal analysis. Nancy Brady: Writing – review & editing, Supervision, Funding acquisition. Elizabeth Berry-Kravis: Investigation, Writing – review & editing. |
ISSN: | 0278-2626 1090-2147 |
DOI: | 10.1016/j.bandc.2021.105694 |