The Stacked-Ellipse Algorithm: An Ultrasound-Based 3-D Uterine Segmentation Tool for Enabling Adaptive Radiotherapy for Uterine Cervix Cancer

The stacked-ellipse (SE) algorithm was developed to rapidly segment the uterus on 3-D ultrasound (US) for the purpose of enabling US-guided adaptive radiotherapy (RT) for uterine cervix cancer patients. The algorithm was initialised manually on a single sagittal slice to provide a series of elliptic...

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Published inUltrasound in medicine & biology Vol. 46; no. 4; pp. 1040 - 1052
Main Authors Mason, Sarah A., White, Ingrid M., Lalondrelle, Susan, Bamber, Jeffrey C., Harris, Emma J.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.04.2020
Pergamon Press
Subjects
3-D ultrasound
Adult
Aged
Algorithms
Female
Humans
Image-guided radiotherapy
Imaging, Three-Dimensional - methods
Middle Aged
Segmentation
Ultrasonography, Interventional - methods
Ultrasound-guided radiotherapy
Uterine Cervical Neoplasms - diagnostic imaging
Uterine Cervical Neoplasms - radiotherapy
Uterine cervix cancer
Uterus
Uterus - diagnostic imaging
Uterine cervix cancer
3-D ultrasound
Segmentation
Uterus
Image-guided radiotherapy
Ultrasound-guided radiotherapy
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Summary:The stacked-ellipse (SE) algorithm was developed to rapidly segment the uterus on 3-D ultrasound (US) for the purpose of enabling US-guided adaptive radiotherapy (RT) for uterine cervix cancer patients. The algorithm was initialised manually on a single sagittal slice to provide a series of elliptical initialisation contours in semi-axial planes along the uterus. The elliptical initialisation contours were deformed according to US features such that they conformed to the uterine boundary. The uterus of 15 patients was scanned with 3-D US using the Clarity System (Elekta Ltd.) at multiple days during RT and manually contoured (n = 49 images and corresponding contours). The median (interquartile range) Dice similarity coefficient and mean surface-to-surface-distance between the SE algorithm and manual contours were 0.80 (0.03) and 3.3 (0.2) mm, respectively, which are within the ranges of reported inter-observer contouring variabilities. The SE algorithm could be implemented in adaptive RT to precisely segment the uterus on 3-D US.
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ISSN:0301-5629
1879-291X
DOI:10.1016/j.ultrasmedbio.2019.09.001