Corneal Immune Privilege

This year marks the 100th anniversary of the first successful corneal transplant on a human subject. Corneal allografts enjoy an exceptionally high acceptance, with rejection occurring in less than 10% of the patients who have not previously received a corneal transplant and who do not have underlyi...

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Bibliographic Details
Published inThe ocular surface Vol. 3; no. 4; pp. S-158 - S-160
Main Author Niederkorn, Jerry Y.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2005
Subjects
corneal transplantation
graft rejection
immune privilege
keratoplasty
keratoplasty
graft rejection
immune privilege
corneal transplantation
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Summary:This year marks the 100th anniversary of the first successful corneal transplant on a human subject. Corneal allografts enjoy an exceptionally high acceptance, with rejection occurring in less than 10% of the patients who have not previously received a corneal transplant and who do not have underlying ocular inflammation. Corneal grafts survive even though HLA typing and systemic immunosuppressive drugs are not employed. The remarkable success of corneal transplants is due to a combination of anatomical, physiological, and immunological properties that conspire to prevent the induction and expression of potentially destructive immune responses to the foreign transplant.
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ISSN:1542-0124
1937-5913
DOI:10.1016/S1542-0124(12)70245-8