Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System

• Published in: Vaccines (Basel) Vol. 6; no. 3; p. 37
• Main Authors: Mohsen, Mona O, Gomes, Ariane C, Vogel, Monique, Bachmann, Martin F
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.07.2018; MDPI
• Subjects: Acids; adaptive immune system; Adaptive immunity; Adaptive systems; Antigens; Cytotoxicity; Genomes; Immune response; Immune system; innate immune system; Innate immunity; Lymphatic system; Nanoparticles; Nucleocapsids; Packaging; Proteins; Review; Skin; Structural stability; Surface geometry; Toll-like receptor (TLR); Vaccines; virus-like particle (VLP); Virus-like particles; Viruses; adaptive immune system; Toll-like receptor (TLR); virus-like particle (VLP); innate immune system
• ISSN: 2076-393X; 2076-393X
• DOI: 10.3390/vaccines6030037

Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.