Endothelial Function in Pulmonary Arterial Hypertension: From Bench to Bedside

• Published in: Journal of clinical medicine Vol. 13; no. 8; p. 2444
• Main Authors: Correale, Michele, Chirivì, Francesco, Bevere, Ester Maria Lucia, Tricarico, Lucia, D'Alto, Michele, Badagliacca, Roberto, Brunetti, Natale D, Vizza, Carmine Dario, Ghio, Stefano
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Acids; Blood vessels; Care and treatment; Cytokines; Development and progression; Disease; endothelial dysfunction; Endothelium; Fibroblasts; flow-mediated dilatation; Growth factors; Health aspects; Hemodynamics; Hypoxia; Inflammation; Medical prognosis; Metabolites; Nitric oxide; Oxidative stress; Pathogenesis; Permeability; pulmonary arterial hypertension; Pulmonary arteries; Pulmonary hypertension; Risk factors; Shear stress; Smooth muscle; Veins & arteries; Italy; flow-mediated dilatation; endothelial dysfunction; pulmonary arterial hypertension; pulmonary hypertension
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm13082444

Pulmonary arterial hypertension is a complex pathology whose etiology is still not completely well clarified. The pathogenesis of pulmonary arterial hypertension involves different molecular mechanisms, with endothelial dysfunction playing a central role in disease progression. Both individual genetic predispositions and environmental factors seem to contribute to its onset. To further understand the complex relationship between endothelial and pulmonary hypertension and try to contribute to the development of future therapies, we report a comprehensive and updated review on endothelial function in pulmonary arterial hypertension.