The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment

The role of gut microbiome-intestinal immune complex in the development of colorectal cancer and its progression is well recognized. Accordingly, certain microbial strains tend to colonize or vanish in patients with colorectal cancer. Probiotics, prebiotics, and synbiotics are expected to exhibit bo...

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Bibliographic Details
Published inIntestinal research Vol. 20; no. 1; pp. 31 - 42
Main Authors Kim, Sang Hoon, Lim, Yun Jeong
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Association for the Study of Intestinal Diseases 01.01.2022
대한장연구학회
Subjects
colon neoplasms
intestinal microbiome
prebiotics
probiotics
Review
synbiotics
내과학
Probiotics
Intestinal microbiome
Colon neoplasms
Synbiotics
Prebiotics
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Summary:The role of gut microbiome-intestinal immune complex in the development of colorectal cancer and its progression is well recognized. Accordingly, certain microbial strains tend to colonize or vanish in patients with colorectal cancer. Probiotics, prebiotics, and synbiotics are expected to exhibit both anti-tumor effects and chemopreventive effects during cancer treatment through mechanisms such as xenometabolism, immune interactions, and altered eco-community. Microbial modulation can also be safely used to prevent complications during peri-operational periods of colorectal surgery. A deeper understanding of the role of intestinal microbiota as a target for colorectal cancer treatment will lead the way to a better prognosis for colorectal cancer patients.
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ISSN:1598-9100
2288-1956
DOI:10.5217/ir.2021.00034