Effect of stress on atopic dermatitis: Investigation in patients after the Great Hanshin Earthquake

• Published in: Journal of allergy and clinical immunology Vol. 104; no. 1; pp. 173 - 176
• Main Authors: Kodama, Atsuko, Horikawa, Tatsuya, Suzuki, Takaaki, Ajiki, Wakiko, Takashima, Tsutomu, Harada, Susumu, Ichihashi, Masamitsu
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.07.1999; Elsevier
• Subjects: Adolescent; Adult; Allergic diseases; Atopic dermatitis; bathing; Biological and medical sciences; Child; Child, Preschool; Dermatitis, Atopic - psychology; Disasters; earthquake; environment; Female; Humans; Immunopathology; Logistic Models; Male; Medical sciences; Middle Aged; natural disasters; Regression Analysis; Skin allergic diseases. Stinging insect allergies; stress; Stress, Psychological - physiopathology; Time Factors; Asia; Japan; DHEA; stress; environment; bathing; AD; Atopic dermatitis; CI; earthquake; Human; Allergy; Immunopathology; Skin disease; Etiopathogenesis; Statistical study; Stress; Atopy; Symptomatology; Earthquakes; Environment; Hygiene
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/S0091-6749(99)70130-2

Background: Although a variety of factors are responsible for atopic dermatitis (AD), very little is known about the effect of stress caused by a natural disaster on AD symptoms. Objective: This study was conducted to assess the effect of stress or trauma on the symptoms of AD. Methods: One thousand four hundred fifty-seven patients with AD (745 males and 712 females), diagnosed by using the criteria of the Japanese Dermatology Association, were enrolled in the study. The data were obtained from a self-administered questionnaire given to patients with AD after experiencing the Great Hanshin Earthquake. The data were analyzed by multivariate logistic regression analysis. Patients were divided into 3 groups: area A, severe damage to buildings and houses; area B, mild damage; and control area, no damage. Results: Exacerbation of skin symptoms was found in 38% and 34% of patients in areas A and B, respectively, whereas similar exacerbation was seen in 7% of control patients. Nine percent and 5% of the patients in areas A and B, respectively, showed improvement in their symptoms compared with 1% in the control group. The earthquake caused stress in 63% and 48% of the patients in areas A and B, respectively, but fewer patients felt stress in undamaged areas (19%). Multiple logistic regression analysis revealed that of the factors examined here, subjective distress is the factor that is most responsible for the exacerbation of skin symptoms (odds ratio, 2.98; 95% confidence interval, 2.25-3.96). Conclusion: The results presented here strongly suggest that stress caused by a natural disaster influences AD symptoms. (J Allergy Clin Immunol 1999;104:173-6.)