The potential use of liposome-mediated antiviral therapy

The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of virus diseases. In this review we discuss the potential use of liposomes in the tre...

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Bibliographic Details
Published inAntiviral research Vol. 5; no. 3; p. 179
Main Authors Koff, W C, Fidler, I J
Format Journal Article
LanguageEnglish
Published Netherlands 01.06.1985
Subjects
Adjuvants, Immunologic - therapeutic use
Antiviral Agents - therapeutic use
Cytotoxicity, Immunologic
Humans
Liposomes - administration & dosage
Macrophage Activation
Macrophages - immunology
Macrophages - microbiology
Monocytes - immunology
Mononuclear Phagocyte System - immunology
Phagocytes - immunology
Virus Diseases - drug therapy
Virus Replication
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Summary:The natural targeting of liposomes to cells of the reticuloendothelial system should be exploited to examine whether selective delivery of antiviral or immunomodulatory agents could be beneficial for the treatment of virus diseases. In this review we discuss the potential use of liposomes in the treatment of virus diseases, the targeting of liposome-encapsulated immunomodulators to macrophages in order to render these cells cytolytic for virus-infected cells, and the targeting of liposome-encapsulated antiviral drugs to macrophages to achieve direct suppression of virus replication with in these cells.
ISSN:0166-3542
DOI:10.1016/0166-3542(85)90050-6