Role of microbial burden in aetiology of allergy and asthma

Martinez and Holt review how recent advances in understanding the way the immune system responses develop in early life support the hygiene hypothesis. The hypothesis suggests that changes in the type and level of stimulation from the microbial environment associated with improvements in hygiene may...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 354; pp. SII12 - SII15
Main Authors Martinez, Fernande D, Holt, Patrick G
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.1999
Elsevier Limited
Subjects
Allergies
Animals
Asthma
Asthma - immunology
Humans
Hypersensitivity - genetics
Hypersensitivity - immunology
Immune system
Immune System - growth & development
Infant
Infant, Newborn
Infection - immunology
Microorganisms
Pediatrics
Risk Factors
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - physiology
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Summary:Martinez and Holt review how recent advances in understanding the way the immune system responses develop in early life support the hygiene hypothesis. The hypothesis suggests that changes in the type and level of stimulation from the microbial environment associated with improvements in hygiene may have indirectly influenced the postnatal development of immune functions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(99)90437-3