Staphylococcus aureus: new evidence for intracellular persistence

Many reports have documented that Staphylococcus aureus can invade host cells and persist intracellularly for various periods of time in cell culture models. However, it is not clear whether intracellular persistence of S. aureus also occurs in the course of infections in whole organisms. This is a...

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Published inTrends in microbiology (Regular ed.) Vol. 17; no. 2; pp. 59 - 65
Main Authors Garzoni, Christian, Kelley, William L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2009
Subjects
Animals
Cattle
Female
Host-Pathogen Interactions
Humans
Internal Medicine
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - physiology
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Summary:Many reports have documented that Staphylococcus aureus can invade host cells and persist intracellularly for various periods of time in cell culture models. However, it is not clear whether intracellular persistence of S. aureus also occurs in the course of infections in whole organisms. This is a subject of intense debate and is difficult to assess experimentally. Intracellular persistence would provide S. aureus with an ideal strategy to escape from professional phagocytes and extracellular antibiotics and would promote recrudescent infection. Here, we present a brief overview of the mounting evidence that S. aureus has the potential to internalize and survive within host cells.
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ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2008.11.005