Group A streptococcal emm type prevalence among symptomatic children in Cape Town and potential vaccine coverage

The molecular epidemiology of group A streptococcal pharyngeal infections in children in the Vanguard Community of Cape Town revealed 26 emm types among 157 isolates from 742 subjects. Coverage of a 30-valent vaccine is predicted to be 95% of pharyngitis cases in this population at high risk of rheu...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 33; no. 2; p. 208
Main Authors Engel, Mark E, Muhamed, Babu, Whitelaw, Andrew C, Musvosvi, Munyaradzi, Mayosi, Bongani M, Dale, James B
Format Journal Article
LanguageEnglish
Published United States 01.02.2014
Subjects
Adolescent
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Bacterial Outer Membrane Proteins - genetics
Bacterial Outer Membrane Proteins - immunology
Carrier Proteins - genetics
Carrier Proteins - immunology
Child
Child, Preschool
Humans
Molecular Epidemiology
Pharyngitis - epidemiology
Pharyngitis - microbiology
Prevalence
Rheumatic Fever
South Africa - epidemiology
Streptococcal Infections - epidemiology
Streptococcal Infections - microbiology
Streptococcal Infections - prevention & control
Streptococcal Vaccines - administration & dosage
Streptococcus pyogenes - genetics
Streptococcus pyogenes - immunology
Streptococcus pyogenes - isolation & purification
South Africa
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Summary:The molecular epidemiology of group A streptococcal pharyngeal infections in children in the Vanguard Community of Cape Town revealed 26 emm types among 157 isolates from 742 subjects. Coverage of a 30-valent vaccine is predicted to be 95% of pharyngitis cases in this population at high risk of rheumatic fever.
ISSN:1532-0987
DOI:10.1097/INF.0b013e3182a5c32a