A Method for High-Throughput Screening of Enantioselective Catalysts

About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled s...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 38; no. 12; pp. 1758 - 1761
Main Authors Reetz, Manfred T., Becker, Michael H., Klein, Heinz-Werner, Stöckigt, Detlef
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 14.06.1999
WILEY‐VCH Verlag GmbH
Subjects
Asymmetric catalysis
Combinatorial chemistry
Enzyme catalysis
High-throughput screening
Mass spectrometry
Combinatorial chemistry
High-throughput screening
Enzyme catalysis
Asymmetric catalysis
Mass spectrometry
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Summary:About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo‐enantiomeric products 2 and 3.
Bibliography:ark:/67375/WNG-BMMMDZV9-Z
ArticleID:ANIE1758
istex:2A633A7268EC1F116FB928588F597A49674A3B2E
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19990614)38:12<1758::AID-ANIE1758>3.0.CO;2-8