Metabolic Actions of Adipocyte Hormones: Focus on Adiponectin

The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponec...

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Bibliographic Details
Published inObesity (Silver Spring, Md.) Vol. 14; no. 2S; pp. 9S - 15S
Main Author Ahima, Rexford S.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.2006
Subjects
adipocyte
Adipocytes - secretion
adiponectin
Adiponectin - metabolism
Adiponectin - physiology
Animals
Disease Models, Animal
Energy Metabolism - physiology
glucose
Homeostasis - physiology
Hormones
Humans
inflammation
Insulin resistance
Kinases
leptin
Leptin - metabolism
Lipids
Mice
Mice, Knockout
Obesity - metabolism
Tumor necrosis factor-TNF
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Summary:The obesity epidemic has focused attention on the endocrine function of adipose tissue. Adipose tissue secretes leptin, cytokines, complement factors, and components of the coagulation cascade, most of which are increased in obesity. In contrast, a strong negative correlation exists between adiponectin and adiposity, insulin sensitivity, diabetes, vascular inflammation, and atherosclerosis. Adiponectin treatment in rodents increases insulin sensitivity and reduces lipids and atherogenesis. Chronic and central adiponectin treatment reduces weight, glucose, and lipids. The insulin‐sensitizing action of thiazolidinediones is mediated, in part, through adiponectin. A causal role of adiponectin in diabetes, dyslipidemia, and atherosclerosis has been established in knockout mice. Therefore, adiponectin seems to be a marker of obesity‐related diseases and a potential therapeutic target.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1930-7381
1930-739X
DOI:10.1038/oby.2006.276