Paracetamol poisoning and the kidney

Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis...

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Bibliographic Details
Published inJournal of clinical pharmacy and therapeutics Vol. 18; no. 1; p. 5
Main Authors Jones, A F, Vale, J A
Format Journal Article
LanguageEnglish
Published England 01.02.1993
Subjects
Acetaminophen - metabolism
Acetaminophen - poisoning
Acetylcysteine - adverse effects
Acute Kidney Injury - chemically induced
Chemical and Drug Induced Liver Injury
Drug Overdose
Humans
Kidney
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Summary:Nephrotoxicity is less common than hepatotoxicity in paracetamol overdose but renal tubular damage and acute renal failure occur even in the absence of hepatotoxicity. It is possible that antidotal therapy with agents such as N-acetylcysteine may not prevent renal toxicity and, indeed, on the basis of animal work, may actually potentiate tubular damage. Careful clinical attention should be paid to renal function in patients poisoned with paracetamol.
ISSN:0269-4727
DOI:10.1111/j.1365-2710.1993.tb00560.x