Iron and CF-related anemia: Expanding clinical and biochemical relationships

• Published in: Pediatric pulmonology Vol. 46; no. 2; pp. 160 - 165
• Main Authors: Gifford, A.H., Miller, S.D., Jackson, B.P., Hampton, T.H., O'Toole, G.A., Stanton, B.A., Parker, H.W.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2011; Wiley-Liss
• Subjects: Adult; Anemia - etiology; Anemias. Hemoglobinopathies; Biological and medical sciences; chelator; Cross-Sectional Studies; cystic fibrosis; Cystic Fibrosis - blood; Cystic Fibrosis - complications; Cystic Fibrosis - physiopathology; Diabetes Mellitus - etiology; Diseases of red blood cells; Errors of metabolism; Female; General aspects; Hematologic and hematopoietic diseases; Humans; hypoferremia; iron; Iron - blood; Iron, Dietary - blood; Lung - physiopathology; Male; Medical sciences; Metabolic diseases; Middle Aged; Miscellaneous hereditary metabolic disorders; Pneumology; Prospective Studies; serum; sputum; Sputum - chemistry; Young Adult; Pediatrics; Respiratory disease; Anemia; Metabolic diseases; Cystic fibrosis; Hemopathy; Iron; Genetic disease; hypoferremia; Expanding; Sputum; chelator; Digestive diseases; Serum; Pancreatic disease; Pneumology
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.21335

Introduction This cross‐sectional study was conducted to assess the relationship between iron levels in the plasma and sputum of cystic fibrosis (CF) patients. Methods Demographic, clinical, and iron‐related laboratory data were prospectively obtained from 25 patients with stable clinical features and 14 patients with worsened clinical features since their most recent evaluations. Results Compared to patients with stable clinical features, those who experienced clinical deterioration demonstrated significantly worse lung function and were more frequently malnourished and diabetic. Members of the latter group were also significantly more hypoferremic and had higher sputum iron content than patients with stable clinical features. No significant correlation was found between plasma and sputum iron levels when the groups were analyzed together and separately. Conclusions Sputum iron content does not correlate with iron‐related hematologic tests. Hypoferremia is common in CF and correlates with poor lung function and overall health. Pediatr. Pulmonol. 2011; 46:160–165. © 2011 Wiley‐Liss, Inc.