Cytotoxic response of serum from patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

The serum of 8 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was tested using a chromium release cytotoxicity assay and cultured Schwann cells. Serum was obtained from all patients prior to treatment by plasma exchange, which was beneficial in some patients only. Those patie...

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Bibliographic Details
Published inActa neurologica Scandinavica Vol. 76; no. 1; p. 24
Main Authors Armati, P J, Pollard, J D
Format Journal Article
LanguageEnglish
Published Denmark 01.07.1987
Subjects
Adult
Autoantibodies - analysis
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Cytotoxicity, Immunologic
Female
Humans
Male
Middle Aged
Myelin Sheath - immunology
Plasma Exchange
Polyneuropathies - immunology
Polyradiculoneuropathy - immunology
Polyradiculoneuropathy - therapy
Polyradiculopathy - therapy
Schwann Cells - immunology
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Summary:The serum of 8 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was tested using a chromium release cytotoxicity assay and cultured Schwann cells. Serum was obtained from all patients prior to treatment by plasma exchange, which was beneficial in some patients only. Those patients with high serum cytotoxicity (high chromium release) were those who showed a positive response to plasma exchange.
ISSN:0001-6314
1600-0404
DOI:10.1111/j.1600-0404.1987.tb03539.x